Brain Pathway Responsible For Obesity Found

50% of us suffer the effects of metabolic inflammation and we don’t know it. There normally are no symptoms of pain or swelling or other tell tale signs that we normally think of with inflammation. One huge symptom however, is the inability to lose weight. Some research suggests that a regular regimen of antioxidant supplementation may help. A little grape seed extract here a little acai berry there could go a long way in your weight loss journey.

As always, this isn’t a substitute for eating sensibly and taking daily walks. But it shouldn’t be ignored either. Antioxidants serve a variety of good purposes in your body. Even if you don’t have metabolic inflammation, they do help boost your immune system which couldn’t hurt.

Greg Arnold
How I am losing my big butt

Here is the article that inspired this blog:

Brain Pathway Responsible For Obesity Found: Too Many Calories Send Brain Off Kilter

ScienceDaily (Oct. 3, 2008) — An overload of calories throws critical portions of the brain out of whack, reveals a study in the October 3rd issue of the journal Cell, a Cell Press publication. That response in the brain’s hypothalamus—the “headquarters” for maintaining energy balance—can happen even in the absence of any weight gain, according to the new studies in mice.

The brain response involves a molecular player, called IKKß/NF-κB, which is known to drive metabolic inflammation in other body tissues. The discovery suggests that treatments designed to block this pathway in the brain might fight the ever-increasing spread of obesity and related diseases, including diabetes and heart disease.

“This pathway is usually present but inactive in the brain,” said Dongsheng Cai of the University of Wisconsin-Madison. Cai said he isn’t sure exactly why IKKß/NF-κB is there and ready to spring into action in the brain. He speculates it may have been an important element for innate immunity, the body’s first line of defense against pathogenic invaders, at some time in the distant past.

“In today’s society, this pathway is mobilized by a different environmental challenge—overnutrition,” he said. Once activated, “the pathway leads to a number of dysfunctions, including resistance to insulin and leptin,” both important metabolic hormones…


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